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| 03:30 Sao Paulo – Coritiba : | | |
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| 03:45 Platense – Boca Juniors : | | |
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| 04:00 Alianza Lima – Universidad Tecnica de Cajamarca : | | |
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| 04:00 Houston Dynamo – Los Angeles Galaxy : | | |
| 04:00 Nashville – Inter Miami : | | |
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| 04:30 Monterrey – Juarez : | | |
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| 05:00 Colorado Rapids – Sporting Kansas City : | | |
| 05:00 Real Salt Lake – Minnesota United : | | |
| 06:00 Los Angeles – San Diego : | | |
| 06:00 San Jose Earthquakes – St. Louis City : | | |
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| 06:30 Atlas Guadalajara – Tigres de la UANL : | | |
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| 15:00 S.K. Beveren – Anderlecht : | | |
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| 15:00 Zenit Saint Petersburg – Dynamo Moscow : | | |
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| 15:30 Nordsjaelland – Silkeborg : | | |
| 15:30 Odense – Horsens : | | |
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| 16:00 Watford – Southampton : | | |
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| 16:00 Feyenoord – Go Ahead Eagles : | | |
| 16:00 Twente – PEC Zwolle : | | |
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| 17:30 RAAL La Louviere – Gent : | | |
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| 17:30 Chapecoense – Bahia : | | |
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| 17:30 Lyngby – Midtjylland : | | |
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| 17:30 Krylia Sovetov – Dynamo Makhachkala : | | |
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| 18:15 Ajax – Heerenveen : | | |
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| 18:30 Hartberg – Austria Wien : | | |
| 18:30 WSG Tirol – Red Bull Salzburg : | | |
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| 18:30 Burnley – West Ham United : | | |
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| 18:30 Barcelona – Athletic Bilbao : | | |
| 18:30 Espanyol – Levante UD : | | |
| 18:30 Racing de Santander – Villarreal : | | |
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| 18:30 Eibar – Tenerife : | | |
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| 19:30 Randers – Copenhagen : | | |
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| 19:30 Sporting Cristal – Sport Huancayo : | | |
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| 19:30 Istanbul BFK – Kocaelispor : | | |
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| 20:00 Mechelen – Standard Liege : | | |
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| 20:00 Baltika Kaliningrad – Spartak Moscow : | | |
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| 20:30 Rapid Wien – Grazer AK : | | |
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| 20:30 Burgos – Cordoba : | | |
| 20:30 Girona – Leganes : | | |
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| 20:45 Lommel SK – R. Charleroi : | | |
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| 21:30 Central Cordoba de Santiago – Instituto Atletico Central Cordoba : | | |
| 21:30 Club Atletico Sarmiento Junin – Club Atletico Huracan : | | |
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| 21:30 Pumas UNAM – Queretaro : | | |
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| 21:45 Deportivo Moquegua – Sport Boys : | | |
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| 22:00 Amedspor – BB Erzurumspor : | | |
| 22:00 Besiktas – Eyupspor : | | |
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| 22:15 RC Lens – Paris Saint-Germain : | | |
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| 22:30 CR Vasco da Gama – Santos : | | |
| 22:30 Clube Atletico Mineiro – Gremio Porto Alegrense : | | |
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| 22:30 Deportivo Alaves – Getafe : | | |
| 22:30 Real Madrid – Real Sociedad : | | |
| 22:30 Sevilla – Rayo Vallecano : | | |
| 22:30 Valencia – Real Betis : | | |
| 23:00 Celta – Osasuna : | | |
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| 23:00 Las Palmas – Albacete Balompie : | | |
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| 23:30 Club Atletico Gimnasia y Esgrima – Talleres de Cordoba : | | |
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| 00:00 Cajamarca – Club Universitario de Deportes : | | |
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| 00:30 River Plate Buenos Aires – Argentinos Juniors : | | |
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| 01:00 EC Vitoria Salvador – Botafogo de Futebol e Regatas : | | |
| 01:00 Mirassol – Flamengo : | | |
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| 01:30 Chicago Fire – Portland Timbers : | | |
| 01:30 New York City – Philadelphia Union : | | |
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| 02:00 Corinthians Paulista – Cruzeiro Esporte Clube : | | |
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| 02:30 Club America – Atletico San Luis : | | |
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| 02:45 Barracas Central – Rosario Central : | | |
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| 03:00 Club Cienciano Cusco – Deportivo Garcilaso : | | |
